Who said what: QoTW 18.06.15

Perspectives

Author: AdminPublished: 18 June 2015

Prep: Cook: Serves:

A weekly roundup of our favourite Parkinson’s quotes

“With Parkinson’s you have two choices: You can let it control you, or you can control it. And I’ve chosen to control it”

– US Senator Johnny Isakson insists his Parkinson’s diagnosis will not affect his 2016 bid for re-election

“People all around the world marvel at the joy they gain from dance and how much they learn in the classes”

– Olie Westheimer, executive director of Brooklyn Parkinson Group, reflects on the international success of Dance for PD

“We aren’t victims, we’re strong, amazing people who happen to have a crummy disease, and we want a cure. Young onset Parkinson’s is real and it’s common. It’s not just a disease of older people”

– Kate Matheson, a digital entreupreneur and leading businesswoman – diagnosed with Young Onset Parkinson’s at the age of 35 – has been appointed National Ambassador for Australian charity, Shake It Up

“It is very sci-fi. What I like about it is that I can wear it at home. You have the little screen, and you can follow the moves”

– Joy Esterberg, a Parkinon’s patient who tested new Google Glass software as part of her PD dance class

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New insights on immune cell process and Parkinson’s disease

Insoluble clumps of the protein alpha-synuclein, which can cause damage to brain cells, have been previously linked to Parkinson’s. Now, scientists in Germany, France and the US have uncovered new details on how brain cells respond to these clusters. The researchers discovered that the brain’s immune cells may be able to join together to break down the protein clumps. According to a press release, this was previously unknown. They also found that these neighbouring cells share mitochondria – structures that generate energy for chemical reactions – to help one another. In certain mutations associated with Parkinson’s, this process may be impaired. The researchers hope this insight could inform the development of new therapies. “We have opened the door to a field that will certainly engage researchers for many years to come,” said Professor Dr Michael Heneka, director of the Department of Neurodegenerative Diseases and Geriatric Psychiatry at the University Hospital…

Could analysing skin oil help diagnose Parkinson’s disease?

Parkinson’s disease patients tend to have high levels of oil, known as sebum, on their skin’s surface. Now, a study has suggested that analysing this substance may help when diagnosing the condition. The study revealed that sebum contains significant amounts of genetic material, specifically the molecule ribonucleic acid (RNA). Analysis of RNA contained in sebum – that is, skin surface lipids RNA, or SSL-RNA – could offer insights into a person’s health. Researchers in Japan examined SSL-RNA in men and women with and without Parkinson’s. The results suggested that the SSL-RNA profiles of those with Parkinson’s had “different characteristics” than those without. The researchers then tested whether examining these profiles with machine learning could reveal those who had Parkinson’s – and who didn’t. The team’s algorithm indicated a “relatively robust discriminatory ability,” supporting the further use of SSL-RNA as part of a future “non-invasive” method for diagnosis.

‘Sonic hedgehog’ protein could impact Parkinson’s disease dyskinesia

Dyskinesia is often caused by extended use of the common Parkinson’s medication levodopa – and can be debilitating for those with the condition. Now, researchers in the US may have found a way to suppress these involuntary movements through a protein called ‘sonic hedgehog’. To conduct their study, the team administered levodopa and sonic hedgehog agonists to rodent and non-human primate models of the condition. The results revealed that dopamine neurons use the protein to communicate with other neurons thought to play a role in levodopa-induced dyskinesia. Increased signalling of sonic hedgehog pathways was found to reduce this dyskinesia – providing “novel insight” into its formation and a “potential therapeutic solution”. “What we find,” wrote corresponding study author Professor Andreas Kottmann, “is that in several animal models, by replacing … dopamine together with agonists that mimic the effects of sonic hedgehog, these dyskinesias can be very much suppressed.”

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Who said what: QoTW 18.06.15

Perspectives

Author: AdminPublished: 18 June 2015

Prep: Cook: Serves:

“With Parkinson’s you have two choices: You can let it control you, or you can control it. And I’ve chosen to control it”

“People all around the world marvel at the joy they gain from dance and how much they learn in the classes”

“We aren’t victims, we’re strong, amazing people who happen to have a crummy disease, and we want a cure. Young onset Parkinson’s is real and it’s common. It’s not just a disease of older people”

“It is very sci-fi. What I like about it is that I can wear it at home. You have the little screen, and you can follow the moves”

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Advances

Parkinson’s UK to launch largest plant-based oil trial in the world

Carers' Corner

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Resources & Tools

What’s going on in Washington DC, and what does it mean for people with Parkinson’s?

New insights on immune cell process and Parkinson’s disease

Could analysing skin oil help diagnose Parkinson’s disease?

‘Sonic hedgehog’ protein could impact Parkinson’s disease dyskinesia

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Who said what: QoTW 18.06.15

Perspectives

Author: AdminPublished: 18 June 2015

“With Parkinson’s you have two choices: You can let it control you, or you can control it. And I’ve chosen to control it”

“People all around the world marvel at the joy they gain from dance and how much they learn in the classes”

“We aren’t victims, we’re strong, amazing people who happen to have a crummy disease, and we want a cure. Young onset Parkinson’s is real and it’s common. It’s not just a disease of older people”

“It is very sci-fi. What I like about it is that I can wear it at home. You have the little screen, and you can follow the moves”

Last Month

Next Month

Share this story

Comments

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Advances

Parkinson’s UK to launch largest plant-based oil trial in the world

Carers' Corner

World Poetry Day: Parkinson’s, marriage and grief

Resources & Tools

What’s going on in Washington DC, and what does it mean for people with Parkinson’s?

New insights on immune cell process and Parkinson’s disease

Could analysing skin oil help diagnose Parkinson’s disease?

‘Sonic hedgehog’ protein could impact Parkinson’s disease dyskinesia

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