Who said what: 4 powerful Parkinson’s quotes we loved this week

Perspectives

Author: Parkinson's Life editorsPublished: 14 May 2015

Prep: Cook: Serves:

A weekly roundup of our favourite Parkinson’s related quotes, as selected by the Parkinson’s Life editorial team:

“The rope is representative of that battle, the need to hold on, to be fighting every day”

– Michael McCastle, US Navy officer who is rope-climbing the height of Everest after losing his father to Parkinson’s

“I will meet this challenge with the same determination and unwavering intensity that I have displayed in all of my endeavours in life”

– Kirk Gibson, former baseball player on his diagnosis

*“With Parkinson’s, sometimes you wake up and think: ‘Why the f*** did they pick me?’ But, you know, that’s part of life”*

– Freddie Roach, trainer of boxer Manny Paquiao

“The amount of new knowledge in the field of Parkinson’s disease gained in the past five years exceeds everything we knew from the previous 200 years”

– John Jurenko, healthcare research philanthropist who recently passed away after living with Parkinson’s

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New insights on immune cell process and Parkinson’s disease

Insoluble clumps of the protein alpha-synuclein, which can cause damage to brain cells, have been previously linked to Parkinson’s. Now, scientists in Germany, France and the US have uncovered new details on how brain cells respond to these clusters. The researchers discovered that the brain’s immune cells may be able to join together to break down the protein clumps. According to a press release, this was previously unknown. They also found that these neighbouring cells share mitochondria – structures that generate energy for chemical reactions – to help one another. In certain mutations associated with Parkinson’s, this process may be impaired. The researchers hope this insight could inform the development of new therapies. “We have opened the door to a field that will certainly engage researchers for many years to come,” said Professor Dr Michael Heneka, director of the Department of Neurodegenerative Diseases and Geriatric Psychiatry at the University Hospital…

Could analysing skin oil help diagnose Parkinson’s disease?

Parkinson’s disease patients tend to have high levels of oil, known as sebum, on their skin’s surface. Now, a study has suggested that analysing this substance may help when diagnosing the condition. The study revealed that sebum contains significant amounts of genetic material, specifically the molecule ribonucleic acid (RNA). Analysis of RNA contained in sebum – that is, skin surface lipids RNA, or SSL-RNA – could offer insights into a person’s health. Researchers in Japan examined SSL-RNA in men and women with and without Parkinson’s. The results suggested that the SSL-RNA profiles of those with Parkinson’s had “different characteristics” than those without. The researchers then tested whether examining these profiles with machine learning could reveal those who had Parkinson’s – and who didn’t. The team’s algorithm indicated a “relatively robust discriminatory ability,” supporting the further use of SSL-RNA as part of a future “non-invasive” method for diagnosis.

‘Sonic hedgehog’ protein could impact Parkinson’s disease dyskinesia

Dyskinesia is often caused by extended use of the common Parkinson’s medication levodopa – and can be debilitating for those with the condition. Now, researchers in the US may have found a way to suppress these involuntary movements through a protein called ‘sonic hedgehog’. To conduct their study, the team administered levodopa and sonic hedgehog agonists to rodent and non-human primate models of the condition. The results revealed that dopamine neurons use the protein to communicate with other neurons thought to play a role in levodopa-induced dyskinesia. Increased signalling of sonic hedgehog pathways was found to reduce this dyskinesia – providing “novel insight” into its formation and a “potential therapeutic solution”. “What we find,” wrote corresponding study author Professor Andreas Kottmann, “is that in several animal models, by replacing … dopamine together with agonists that mimic the effects of sonic hedgehog, these dyskinesias can be very much suppressed.”

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Who said what: 4 powerful Parkinson’s quotes we loved this week

Perspectives

Author: Parkinson's Life editorsPublished: 14 May 2015

Prep: Cook: Serves:

“The rope is representative of that battle, the need to hold on, to be fighting every day”

“I will meet this challenge with the same determination and unwavering intensity that I have displayed in all of my endeavours in life”

*“With Parkinson’s, sometimes you wake up and think: ‘Why the f*** did they pick me?’ But, you know, that’s part of life”*

“The amount of new knowledge in the field of Parkinson’s disease gained in the past five years exceeds everything we knew from the previous 200 years”

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Europe

UK Prime Minister hosts reception to mark 200 years since the discovery of Parkinson’s

Global update

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Sign up for the Parkinson’s football ‘world cup’

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Could analysing skin oil help diagnose Parkinson’s disease?

‘Sonic hedgehog’ protein could impact Parkinson’s disease dyskinesia

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Who said what: 4 powerful Parkinson’s quotes we loved this week

Perspectives

Author: Parkinson's Life editorsPublished: 14 May 2015

Prep: Cook: Serves:

“The rope is representative of that battle, the need to hold on, to be fighting every day”

“I will meet this challenge with the same determination and unwavering intensity that I have displayed in all of my endeavours in life”

“With Parkinson’s, sometimes you wake up and think: ‘Why the f*** did they pick me?’ But, you know, that’s part of life”

“The amount of new knowledge in the field of Parkinson’s disease gained in the past five years exceeds everything we knew from the previous 200 years”

Last Month

Next Month

Share this story

Comments

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Europe

UK Prime Minister hosts reception to mark 200 years since the discovery of Parkinson’s

Global update

Parkinson’s Awareness Month 2017: global celebrations

Health & Fitness

Sign up for the Parkinson’s football ‘world cup’

New insights on immune cell process and Parkinson’s disease

Could analysing skin oil help diagnose Parkinson’s disease?

‘Sonic hedgehog’ protein could impact Parkinson’s disease dyskinesia

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*“With Parkinson’s, sometimes you wake up and think: ‘Why the f*** did they pick me?’ But, you know, that’s part of life”*