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New enzyme discovery could “put the brakes” on Parkinson’s

Researchers at the University of Dundee, UK, have discovered an enzyme that could reverse mutations in a gene commonly associated with the development of Parkinson’s. The enzyme, called PPM1H, has been found to naturally prevent the biological activity of LRKK2 – it is hoped this discovery could slowdown the progression of the disease. The researchers are now working with the university’s Drug Discovery Unit to develop compounds that could activate the newly discovered enzyme. Professor Dario Alessi, one of the lead researchers, said: “Parkinson’s is like a runaway train – at present we have no way of putting the brakes on to slow it down, let alone stop it. This new enzyme we have found acts as the brakes in the pathway that causes Parkinson’s in humans. “This finding opens the door for a new chemical approach to the search for Parkinson’s treatments.” Lead image credit: University of Dundee

£2 million ballet and Parkinson’s study launched

A new study launched by English National Ballet and university King’s College London, UK, will assess the impact of ballet on Parkinson’s symptoms. Researchers hope that regular lessons – which include voice exercises and dance – will improve fluidity, gait and posture in people living with the condition. The study is part of a wider project, costing in the region of UK £2 million, researching how the arts impacts physical and mental health. Fleur Derbyshire-Fox, English National Ballet’s Engagement Director, said: “Since creating our Dance for Parkinson’s programme in 2010 we have seen first-hand the incredible effects dance can have on a person living with Parkinson’s. “We’re thrilled to be a part of this study, with the opportunity to embed the programme within secondary care, and in turn have a greater impact on the physical and emotional wellbeing of people living with Parkinson’s.”

Parkinson’s trial awarded £250,000 by UK Medical Research Council

Researchers from UK university Imperial College London have been awarded UK £250,000 to trial surgical implants that could reduce the number of falls in patients with Parkinson’s. The funding has been awarded by the Medical Research Council – the body responsible for co-ordinating research in the UK. As part of the trial, the implants will alter nerve activity by sending a low-voltage current to different areas of the spinal cord in five patients living with Parkinson’s disease. Dr Yen Tai, from the Department of Brain Sciences at Imperial College London, said: “Frequent falls are a common and disabling problem in advanced Parkinson’s, and can lead to patient’s being housebound. “This grant will enable me to work in collaboration with the Brain and Vestibular Group at the College and the Trust, to trial a new treatment that could help improve outcomes for patients and how we deliver care.”