Study suggests why neurons die in Parkinson’s disease


Author: Sarah McGrathPublished: 19 May 2022

Parkinson's LifePrep: Parkinson's LifeCook: Parkinson's LifeServes:

Researchers at the University of Córdoba, Spain, have discovered how a certain protein may be linked to death of dopamine-producing neurons associated with Parkinson’s.

Using animal models of the condition to conduct their study, the team focused on the protein DJ-1 – whose link to Parkinson’s has previously been established, though its exact function was uncertain. The researchers compared neurons in the brains of mice that possessed the gene expressing DJ-1 with those that did not.

The findings revealed that dysfunction or absence of the gene expressing the DJ-1 protein could trigger the ‘cell cycle’ (the process by which cells divide), which should not occur under normal conditions. Because neurons lack the capacity to divide, this causes them die – leading to the onset of symptoms linked with Parkinson’s.

It is hoped that uncovering these details about the relationship between DJ-1’s absence and Parkinson’s may lead to the development of new therapies.

 Read more:

Researchers have finally identified brain cells linked to Parkinson’s disease

Tiny DBS implant shows potential to advance Parkinson’s disease treatment

Go Back

Share this story


Related articles

News image


Brain-stimulating headwear may alleviate Parkinson’s symptoms

A new non-invasive, three-pronged helmet could act as an alternative for de

Shot of a woman teleworking in a cafe using a digital tablet


New app could help people with Parkinson’s disease navigate their browsers

Marking Parkinson’s Awareness Month, advertising company Havas Creative h



A new technique for isolating brain cells linked to Parkinson’s

Researchers at Carnegie Mellon University, US, have developed a new techniq