Researchers create Parkinson’s-resistant stem cells

Scientists at the University of Edinburgh, UK, have created stem cells that they say are resistant to developing Parkinson’s.

The study – published in science journal ‘European Journal of Neuroscience’ – used gene editing techniques to remove the alpha-synuclein protein from the stem cells. To test the resistance of the new stem cells, researchers treated both edited and unedited stem cells with a chemical agent that induced Lewy bodies – abnormal proteins that lead to neurodegeneration.

The results showed that the gene-edited cells did not develop signs of Parkinson’s, whereas the unedited cells did.

Dr Tilo Kunath – who led the study – said: “We know that Parkinson’s disease spreads from neuron-neuron, invading healthy cells. This could essentially put a shelf life on the potential of cell replacement therapy. Our exciting discovery has the potential to considerably improve these emerging treatments.”

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