Parkinson’s could be present from birth, study finds

News

Author: Caithlin NgPublished: 6 February 2020

Parkinson's LifePrep: Parkinson's LifeCook: Parkinson's LifeServes:

Parkinson’s may be present from birth in younger people with the condition, new research has found.

The study – conducted by Cedars-Sinai Medical Centre, US, and published in ‘Nature Medicine’ journal – used induced stem cells from people with young-onset Parkinson’s, to grow dopamine-producing neurons and observe them for early warning signs of the condition.

An abnormal pile-up of protein was found during the neurons’ development, including alpha-synuclein; which occurs in Parkinson’s. The scientists conjecture that Parkinson’s symptoms appear when the pile-up continues over 20 or 30 years.

The team also found that the drug PEP005 – currently used against skin precancers – could help treat the condition.

Michele Tagliati, vice chair and professor at Cedars-Sinai’s Department of Neurology and the study’s co-author, said: “This exciting new research provides hope that one day we may be able to detect and take early action to prevent this disease in at-risk individuals.”

Lead image credit: Clive Svendsen, PhD, director of the Cedars-Sinai Board of Governors Regenerative Medicine Institute, right, and Nur Yucer, PhD, a project scientist, discuss a microscope image of dopamine neurons. Photo by Cedars-Sinai.

To read more on this topic click here.

For more information on the latest Parkinson’s research please visit the EPDA website.


Read more :

Testing saliva can help diagnose Parkinson’s, study finds

Can a digital pen « revolutonise » Parkinson’s diagnosis ?

Go Back

Share this story

Comments


Related articles


Older woman looking at mirror

PD in Practice

How does facial masking affect people with Parkinson’s?

Find out what causes hypomimia – and how the symptom can be treated

READ MORE
Unite for Parkinson's team

Global update

#UniteForParkinsons campaign wins ‘highly commended’ award

Parkinson’s Life and partners recognised in ‘Best Charity Campaign’ a

READ MORE

Recipes & Nutrition

Parki’s Kookatelier: fish soup ‘a la Bouillabaisse’

'A la Bouillabaisse': A tasty seafood dish

READ MORE