Parkinson’s podcast: stopping disease progression

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Author: Geoffrey ChangPublished: 9 July 2015

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In the second episode of the Portland Countdown podcast series, Dr Patrik Brundin and Dr Kimberley Gannon discuss how to stop ‘bad’ proteins attacking brain cells

Stopping disease progression: alpha synuclein

Special Guests: Patrik Brundin, MD, PhD and Kimberley Gannon, PhD

Basic researchers are hard at work trying to understand the pathology of Parkinson’s and discover new drug targets. One likely bad actor is a protein called alpha-synuclein.

Hosted by Dave Iverson and Jon Palfreman, Emmy award-winning journalists living with Parkinson’s disease, this episode looks into what we know about how alpha-synuclein kills brain cells and what might be done to stop it, with Dr Patrik Brundin and Dr Kimberley Gannon on hand to offer their expert opinions.

The aim of the Portland Countdown series is to give listeners new perspectives on the latest advances in Parkinson’s research and treatment.

The shows, developed by the World Parkinson Coalition, are aired online on the first Tuesday of every month from June 2015 to September 2016 – when the 4th World Parkinson Congress takes place in Portland, Oregon, USA. The entire series of podcasts will also be downloadable for free.

The full schedule of show topics and guest speaker profiles is available here

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Acupuncture may alleviate Parkinson’s symptoms

A study conducted by researchers in South Korea has found that acupuncture may help alleviate motor symptoms of Parkinson’s. The study – published in science journal ‘Frontiers in Aging Neuroscience’ – collected data from 42 existing trials testing the effects of acupuncture on different mouse models of Parkinson’s disease. A total of 40 studies showed that acupuncture increased levels of tyrosine hydroxylase – an enzyme in the brain which is part of the dopamine-producing process. Although there was no evidence to suggest acupuncture can induce changes in dopamine levels, results suggested that acupuncture may help alleviate motor symptoms in mice. Discussing their findings, the researchers commented: “Acupuncture treatment potentially protected [dopamine] neurons through various beneficial mechanisms. “Nevertheless, resolving the low quality of studies and further research investigating the efficacy of different acupuncture treatment methods in Parkinson’s disease rodent models will be needed.”

Could insulin be used to treat Parkinson’s symptoms?

A US study has found that intranasal insulin, which is commonly used to treat diabetes, may be able to improve Parkinson’s symptoms. As part of the study, published in scientific journal ‘PLOS ONE’, 14 people with Parkinson’s were administered a daily dose of intranasal insulin for four weeks. After the four week period, researchers – made up staff from Harvard Medical School, US, and the University of Massachusetts, US – saw an improvement in both the participants motor skills and verbal fluency. Discussing the trial, the researchers said: “Our study provided preliminary data that suggested an improvement of functional skills after four weeks of daily INI [intranasal insulin] treatment. That paves the way toward a larger cohort study to evaluate long-term safety and potential efficacy of intranasal insulin administration for potential treatment and prevention of functional decline in patients with Parkinson disease”.

Can drinking milk increase the risk of Parkinson’s?

Researchers at Uppsala University, Sweden, have found that drinking more than 40 millilitres of milk per day may increase the risk of developing Parkinson’s. As part of the study, 81,889 participants between the ages of 45 and 83 who do not live with the condition completed a survey detailing their milk, soured milk and yoghurt consumption. After an average follow up of 14 years, a total of 1,251 participants reported a Parkinson’s diagnosis. The dietary patterns of the participants showed that individuals who drank 40 to 159 millilitres of milk per day were 30% more likely to develop the condition. The researchers – who presented their study at the 2019 International Conference on Alzheimer’s and Parkinson’s Diseases in Lisbon, Portugal – concluded: “Findings from this cohort study indicate that consumption of milk, but not soured milk and yogurt, is associated with an increased risk of Parkinson’s disease.”

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Parkinson’s podcast: stopping disease progression

Resources & Tools

Author: Geoffrey ChangPublished: 9 July 2015

Prep: Cook: Serves:

Last Month

Next Month

Share this story

Comments

Perspectives

Michael J Fox Foundation CEO hails advances in Parkinson’s treatment

Special reports

Why we should treat this ‘damaging’ study on physiotherapy in Parkinson’s with caution

Interviews

May May Ali: “My father was misdiagnosed for years”

Acupuncture may alleviate Parkinson’s symptoms

Could insulin be used to treat Parkinson’s symptoms?

Can drinking milk increase the risk of Parkinson’s?

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Parkinson’s podcast: stopping disease progression

Resources & Tools

Author: Geoffrey ChangPublished: 9 July 2015

Prep: Cook: Serves:

Last Month

Next Month

Share this story

Comments

Related articles

Perspectives

Michael J Fox Foundation CEO hails advances in Parkinson’s treatment

Special reports

Why we should treat this ‘damaging’ study on physiotherapy in Parkinson’s with caution

Interviews

May May Ali: “My father was misdiagnosed for years”

Acupuncture may alleviate Parkinson’s symptoms

Could insulin be used to treat Parkinson’s symptoms?

Can drinking milk increase the risk of Parkinson’s?

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