New enzyme discovery could “put the brakes” on Parkinson’s

News

Author: Roisin McCormackPublished: 14 November 2019

Parkinson's LifePrep: Parkinson's LifeCook: Parkinson's LifeServes:

Professor Dario Alessi University of Dundee

Researchers at the University of Dundee, UK, have discovered an enzyme that could reverse mutations in a gene commonly associated with the development of Parkinson’s.

The enzyme, called PPM1H, has been found to naturally prevent the biological activity of LRKK2 – it is hoped this discovery could slowdown the progression of the disease.

The researchers are now working with the university’s Drug Discovery Unit to develop compounds that could activate the newly discovered enzyme.

Professor Dario Alessi, one of the lead researchers, said: “Parkinson’s is like a runaway train – at present we have no way of putting the brakes on to slow it down, let alone stop it. This new enzyme we have found acts as the brakes in the pathway that causes Parkinson’s in humans.

“This finding opens the door for a new chemical approach to the search for Parkinson’s treatments.”

Lead image credit: University of Dundee

To read more on this topic click here.


Read more:

£2 million ballet and Parkinson’s study launched

Researchers awarded £250,000 by UK Medical Research Council

Go Back

Share this story

Comments


Related articles


Hangzhou Parkinson's Society

In my country

Building a Parkinson’s network in China

Assessing the Parkinson’s infrastructure in China

READ MORE
Jessica Mann

Interviews

Jessica Mann: writing with Parkinson’s

We talk to the British author about living with Parkinson’s for two decad

READ MORE
Parkinson's Sidekicks

Interviews

Parkinson’s Sidekicks: bridging the intergenerational gap

A US art initiative tackling social isolation in Parkinson’s

READ MORE