New enzyme discovery could “put the brakes” on Parkinson’s

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Author: Roisin McCormackPublished: 14 November 2019

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Professor Dario Alessi University of Dundee

Researchers at the University of Dundee, UK, have discovered an enzyme that could reverse mutations in a gene commonly associated with the development of Parkinson’s.

The enzyme, called PPM1H, has been found to naturally prevent the biological activity of LRKK2 – it is hoped this discovery could slowdown the progression of the disease.

The researchers are now working with the university’s Drug Discovery Unit to develop compounds that could activate the newly discovered enzyme.

Professor Dario Alessi, one of the lead researchers, said: “Parkinson’s is like a runaway train – at present we have no way of putting the brakes on to slow it down, let alone stop it. This new enzyme we have found acts as the brakes in the pathway that causes Parkinson’s in humans.

“This finding opens the door for a new chemical approach to the search for Parkinson’s treatments.”

Lead image credit: University of Dundee

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Researchers awarded £250,000 by UK Medical Research Council

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New enzyme discovery could “put the brakes” on Parkinson’s

News

Author: Roisin McCormackPublished: 14 November 2019

Prep: Cook: Serves:

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Podcast: How to eat well with Parkinson’s disease

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“There is nothing wrong with my head and I will not be judged by my condition”

Special reports

Lewy body dementia: “The worst of Parkinson’s and Alzheimer’s together”

Wearable device for Parkinson’s disease raises $10m in funding

Does Parkinson’s disease start in the nose?

Study finds gene therapy may restore effects of Parkinson’s drug

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New enzyme discovery could “put the brakes” on Parkinson’s

News

Author: Roisin McCormackPublished: 14 November 2019

Last Month

Next Month

Share this story

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Related articles

Episodes

Podcast: How to eat well with Parkinson’s disease

Interviews

“There is nothing wrong with my head and I will not be judged by my condition”

Special reports

Lewy body dementia: “The worst of Parkinson’s and Alzheimer’s together”

Wearable device for Parkinson’s disease raises $10m in funding

Does Parkinson’s disease start in the nose?

Study finds gene therapy may restore effects of Parkinson’s drug

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