Mouse study suggests neurodegenerative disease begins soon after birth

News

Author: Parkinson's Life editorsPublished: 22 May 2018

Parkinson's LifePrep: Parkinson's LifeCook: Parkinson's LifeServes:

Mouse research

A study published in the ‘Journal of Clinical Investigation’ has suggested mechanisms that lead to Parkinson’s in adulthood, may begin much earlier than previously thought.

The study, carried out by Northwestern University, Illinois, US, researched movement disorder spinocerebellar ataxia type 1 by genetically engineering a mouse to mirror the human disease.

Researchers found that altering circuity in the cerebellum – an area of the brain that controls movements – set the stage for later susceptibility to neurological disease.

Professor Puneet Opal, who worked on the study, said: “This is the first discovery of alterations in an adult-onset spinocerebellar disorder that stems from such early developmental processes.

“This may well be generalisable to a whole host of other diseases, including Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and amyotrophic lateral sclerosis.”

For a collection of the latest Parkinson’s-related research papers please visit the EPDA website here.

Go Back

Share this story

Comments


Related articles


artificial intelligence

Advances

Parkinson’s AI trial launched by Chinese tech giant

The study will take place in London

READ MORE
PL_John L Lehr PDF CEO lead

Interviews

John Lehr: “I’m inspired by the persistent hope of those living with Parkinson’s”

PDF CEO unveils plans for organisation’s 60th anniversary year

READ MORE

Global update

Sign up to be part of ‘world-first’ global health study into Parkinson’s disease

Innovative smartphone app to gather data for global health study

READ MORE