People with depression ‘more likely’ to develop Parkinson’s

Advances

Author: Parkinson's Life editorsPublished: 28 May 2015

Parkinson's LifePrep: Parkinson's LifeCook: Parkinson's LifeServes:

iStock_000043614398_Large

A new study reveals that the links between depression and Parkinson’s could be deeper than previously thought – in fact, depression may be an early risk factor for the development of Parkinson’s 

People with depression may be more likely to develop Parkinson’s disease, according to a new study by researchers in Sweden.

The large-scale study, published in the online issue of Neurology®, the medical journal of the American Academy of Neurology, followed participants for put to 26 years to explore links between the two diseases.

Study author Peter Nordström, PhD, of Umeå University in Sweden, said: “We saw this link between depression and Parkinson’s disease during over a timespan of more than two decades, so depression may be a very early symptom of Parkinson’s disease or a risk factor for the disease.”

The researchers also examined siblings, and found no link between one sibling having depression and the other having Parkinson’s disease. “This finding gives us more evidence that these two diseases are linked,” said Nordström. “If the diseases were independent of each other but caused by the same genetic or early environmental factors, then we would expect to see the two diseases group together in siblings, but that didn’t happen.”

For the study, researchers started with all Swedish citizens age 50 and older at the end of 2005. From that, they took the 140,688 people who were diagnosed with depression from 1987 to 2012. These people were then matched with three control participants of the same sex and year of birth who had not been diagnosed with depression, for a total of 421,718 control participants.

The participants were then followed for up to 26 years. During this time, 1,485 people with depression developed Parkinson’s disease, or 1.1 percent, while 1,775 people, or 0.4 percent of those who did not have depression, developed Parkinson’s disease.

Parkinson’s disease was diagnosed an average of 4.5 years after the start of the study. The likelihood of developing Parkinson’s disease decreased over time. People with depression were 3.2 times more likely to develop Parkinson’s disease within a year after the study started than people who did not have depression. By 15 to 25 years after the study started, people with depression were about 50 percent more likely to develop Parkinson’s disease.

People with more serious cases of depression were also more likely to develop Parkinson’s disease. People who had been hospitalized for depression five or more times were 40 percent more likely to develop Parkinson’s disease than people who had been hospitalized for depression only one time. People who had been hospitalized for depression were also 3.5 times more likely to develop Parkinson’s disease than people who had been treated for depression as outpatients.

The link between depression and Parkinson’s disease did not change when researchers adjusted for other conditions related to depression, such as traumatic brain injury, stroke and alcohol and drug abuse.

Go Back

Share this story

Comments


  • http://www.mikebell.eu mikebell

    True for me.. Depth of depression which came in middle of beautiful life, and now PD.

Related articles


Parkinson's UK London Marathon 2017 lead

Europe

Run for Parkinson’s: campaigners raise £321,000 at London marathon

A snapshot of the campaigners who ran for Parkinson's

READ MORE
Meal Soup lead

Recipes & Nutrition

In the kitchen with Yves: why meal soups are good for you

Turning soup into a filling dish that is easy to chew and swallow

READ MORE
Tony challenge completed

Europe

Tony’s two-wheel tour: Parkinson’s promise fulfilled, challenge completed!

Tony describes how he completed his Parkinson’s 100 Challenge

READ MORE